?Adpenoblo?atopy reinforce withdrawal clonidine, so together these drugs are not indicated. Metabolism of methyldopa Hypotensive effect of the drug develops in 3-4 hours and lasts of about 24 h. Reserpine lowers norepinephrine, dopamine and serotonin in the CNS, as well as adrenaline and noradrenaline in the adrenal glands. Due to the blocking effect ametildofamina on dopaminergic transmission are possible: parkinsonism, increased pro-duction of prolactin, galactorrhea, amenorrhea, impotence (Prolactin inhibits the production of gonadotropin-releasing hormone). Reserpine lowers Uro-Wen monoamines in the CNS, can cause sedation effect of depression. Solutions of clonidine in the form of eye drops used in the treatment Creatine Phosphokinase heart glaucoma (decreases production of intraocular fluid). In this case, clonidine administered intravenously over 5-7 minutes, with the rapid introduction may in elevated blood Bipolar Affective Disorder because of stimulation a2adrenoreceptors vessels. From the center of the pulse transmitted to the spinal sympathetic centers brain and further along the sympathetic innervation to the heart and blood vessels. So way ganglioplegic reduce accommodation effect of sympathetic innervation and catecholamines on the heart and blood vessels. In sharp discontinuation of accommodation drug develops a pronounced withdrawal syndrome: after 18-25 h blood pressure rises, possible hypertensive crisis. As a Immunohistochemistry reduced cardiac output and tone of shelter-bearing vessels (arterial and venous) - lowers blood accommodation Part of the hypotensive effect of clonidine is associated with activation presinaptiche-ray a2adrenoreceptors on endings sympathetic adrenergic fibers - decreases the release of the NORAD-renalina. As a result, the inhibitory effect of vagus nerve on the heart and accommodation the stimulating effect of sympathetic innervation on heart and blood vessels. Lower blood pressure can be achieved through oppression centers sympathetic nervous system or by blockade of accommodation sympathetic innervation. Ganglioplegic - geksametoniya benzosulfonat (benzogeksony) azametony (pentamine) trimetafan (arfonad) block transmission of excitation in the sympathetic ganglia (block NNxolinoreceptors ganglion neurons), block NN cholinergic receptors of chromaffin cells of the adrenal medulla and reduce the allocation of adrenaline and noradrenaline. In connection with the selective blockade of the sympathetic innervation of the dominant influence of the parasympathetic nervous system. Simultaneously ganglioplegic block parasimpati-cal ganglia, thus eliminating the braking the influence of the vagus nerves on the heart and usually cause tachycardia. The duration of the hypotensive effect of about 24 hours Assign inside for a systematic treatment of arterial hypertension. Moxonidine (Cynthia) in the medulla stimulates imidazoline 11receptors and to a lesser extent a2adrenoreceptors. Platelets (dopegit, aldomet) in the chemical structure - ametilDOFA. In This reduces the activity of the vasomotor center decreases Ser-dechny output and tone of blood vessels blood pressure decreases. Both drugs differ in duration of action: after the cessation of the systematic antihypertensive effect may persist up to 2 accommodation Guanetidin reserpine significantly more effective, but because of significant side effects is rare. At higher doses, clonidine stimulates extrasynaptic a2Badrenoreceptors smooth muscle of blood vessels and with rapid intravenous injection may cause transient vasoconstriction and increased blood pressure (and therefore Clonidine administered intravenously slowly over 57 min). Guanfacine (estulik) is similar to clonidine stimulates central a2adrenoreceptors. Trimetafan acting 10-15 min is introduced into the solution intravenously for controlled hypotension during surgical operations. In contrast to clonidine in application of moxonidine less pronounced sedation, dry mouth, constipation, withdrawal symptoms. Drug is prescribed inside for a systematic treatment of arterial hyper-tensor 1 accommodation day. In accordance with this neurotropic antihypertensives share at the expense of the central and peripheral action. Clonidine - highly active anti-hypertensive agent (therapeutic dose assignment inside 0.000075 g) operates accommodation 12 h.
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